San Francisco Giants vs St. Louis Cardinals Prediction, Picks and Head-to-Head

San Francisco GiantsVS

St. Louis Cardinals

Head to Head

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Our Picks in This Matchup

Every breakdown we have published between these two teams, graded against the final score.

Side Picks

4-2 · 67%

Total Picks

3-2 · 60%

Wed, Sep 16 · SF 6, STL 5

W San Francisco Giants MLPENDING Over

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Tue, Sep 15 · SF 10, STL 3

L St. Louis Cardinals MLW Over 8

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Mon, Sep 14 · SF 1, STL 2

L San Francisco Giants MLL Over 7.5

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Wed, Sep 9 · SF 7, STL 6

W San Francisco Giants MLW Over 8

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Tue, Sep 8 · SF 2, STL 1

W San Francisco Giants MLL Over 7.5

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Mon, Sep 7 · SF 5, STL 4

W San Francisco Giants MLW Over 7.5

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Head to Head

Every meeting this season and last.

Giants wins

Cardinals wins

Giants won 6-5

Wed, Sep 16 · at Cardinals

Giants won 10-3

Tue, Sep 15 · at Cardinals

Cardinals won 2-1

Mon, Sep 14 · at Cardinals

Giants won 7-6

Wed, Sep 9 · at Giants

Giants won 2-1

Tue, Sep 8 · at Giants

Giants won 5-4

Mon, Sep 7 · at Giants

Giants won 4-3

Wed, Sep 24 · at Giants

Cardinals won 9-8

Tue, Sep 23 · at Giants

Cardinals won 6-5

Mon, Sep 22 · at Giants

Cardinals won 4-3

Sun, Sep 7 · at Cardinals

Cardinals won 3-2

Sat, Sep 6 · at Cardinals

Giants won 8-2

Fri, Sep 5 · at Cardinals

Team Comparison

2026 season.

Giants		Cardinals
65-97	Record	77-85
37-44	Home	38-43
28-53	Road	39-42
2-8	Last 10	2-8
L5	Streak	L4

Season stats, league rank in brackets. Longer bar, stronger league standing.

4.2 (23rd)

Runs

(12th) 4.5

(League Avg: 4.5 Runs/Game)

0.713 (20th)

OPS

(26th) 0.697

(League Avg: 0.719 OPS)

30.8% (28th)

OBP

(17th) 31.5%

(League Avg: 31.9%)

0.405 (9th)

SLG

(27th) 0.382

(League Avg: 0.400 SLG)

177 (17th)

(23rd) 161

(League Avg: 179 HR)

8.4 (7th)

Hits

(14th) 8.2

(League Avg: 8.2 Hits/Game)

24.7% (10th)

AVG

(19th) 24.2%

(League Avg: 24.4%)

81 (23rd)

(17th) 97

(League Avg: 106 SB)

4.7 (22nd)

Runs Allowed

(22nd) 4.7

(League Avg: 4.5 Runs/Game)

4.39 (23rd)

ERA

(22nd) 4.29

(League Avg: 4.18 ERA)

1.37 (24th)

WHIP

(23rd) 1.36

(League Avg: 1.31 WHIP)

7.59 (27th)

K/9

(24th) 7.98

(League Avg: 8.49 K/9)

151 (3rd)

HR Allowed

(4th) 155

(League Avg: 179 HR)

8.3 (18th)

Hits Allowed

(24th) 8.6

(League Avg: 8.2 Hits/Game)

24.9% (21st)

BAA

(26th) 25.4%

(League Avg: 24.4%)

98.2% (28th)

FLD%

(8th) 98.7%

(League Avg: 98.6%)

San Francisco Giants team pageFull player stats, roster, injuries ›

St. Louis Cardinals team pageFull player stats, roster, injuries ›

This information is for entertainment purposes only and is not any form of financial or gambling advice. Sports involve high variance therefore always be responsible and manage your risk accordingly.

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