Arizona Cardinals vs San Francisco 49ers Prediction, Picks and Head-to-Head

Arizona CardinalsVS

San Francisco 49ers

Head to Head

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Our Picks in This Matchup

Every breakdown we have published between these two teams, graded against the final score.

Side Picks

1-0 · 100%

Total Picks

0-1 · 0%

Sun, Sep 27 · ARI 30, SF 36

W Arizona Cardinals +8.5L Under 47.5

›

Head to Head

Every meeting this season and last.

Cardinals wins

49ers wins

49ers won 36-30

Sun, Sep 27 · at 49ers

49ers won 41-22

Sun, Nov 16 · at Cardinals

49ers won 16-15

Sun, Sep 21 · at 49ers

Team Comparison

2026 season.

Cardinals		49ers
1-4	Record	5-0
0-2	Home	3-0
1-2	Road	2-0
L4	Streak	W5

Season stats, league rank in brackets. Longer bar, stronger league standing.

21.8 (17th)

Points

(3rd) 30.8

(League Avg: 23.1 Pts/Game)

305.0 (25th)

Total Yards

(10th) 367.8

(League Avg: 346.9 Yds/Game)

194.2 (22nd)

Pass Yards

(13th) 236.4

(League Avg: 221.5 Pass Yds/G)

100.5 (21st)

Rush Yards

(8th) 128.6

(League Avg: 112.0 Rush Yds/G)

39.3% (13th)

3rd Down

(2nd) 51.9%

(League Avg: 39.3%)

57.1% (15th)

Red Zone TD

(1st) 87.5%

(League Avg: 59.9%)

4.64 (32nd)

Yards/Play

(4th) 6.48

(League Avg: 5.61 Yds/Play)

4 (10th)

Giveaways

(10th) 5

(League Avg: 5 Giveaways)

29.2 (29th)

Points Allowed

(3rd) 18.6

(League Avg: 23.0 Pts/Game)

365.2 (22nd)

Yards Allowed

(5th) 308.4

(League Avg: 346.7 Yds/Game)

233.8 (23rd)

Pass Yds Allowed

(8th) 199.6

(League Avg: 221.4 Pass Yds/G)

117.5 (20th)

Rush Yds Allowed

(10th) 97.6

(League Avg: 111.8 Rush Yds/G)

45.5% (25th)

3rd Down Def

(19th) 40.8%

(League Avg: 39.3%)

69.2% (25th)

Red Zone Def

(11th) 53.8%

(League Avg: 59.8%)

8 (16th)

Sacks

(12th) 11

(League Avg: 9 Sacks)

7 (6th)

Takeaways

(10th) 7

(League Avg: 5 Takeaways)

Arizona Cardinals team pageFull player stats, roster, injuries ›

San Francisco 49ers team pageFull player stats, roster, injuries ›

This information is for entertainment purposes only and is not any form of financial or gambling advice. Sports involve high variance therefore always be responsible and manage your risk accordingly.

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