Denver Broncos vs San Francisco 49ers Prediction, Picks and Head-to-Head
Our Picks in This Matchup
Every breakdown we have published between these two teams, graded against the final score.
Side Picks
1-0 · 100%
Total Picks
1-0 · 100%
Sun, Oct 4 · DEN 14, SF 24
W San Francisco 49ers -3W Under 45.5
Head to Head
Every meeting this season and last.
Broncos wins
0
49ers wins
1

49ers won 24-14
Sun, Oct 4 · at 49ers
Team Comparison
2026 season.
| Broncos | 49ers | |
|---|---|---|
| 3-2 | Record | 5-0 |
| 2-0 | Home | 3-0 |
| 1-2 | Road | 2-0 |
| W1 | Streak | W5 |
Season stats, league rank in brackets. Longer bar, stronger league standing.
Denver Broncos team pageFull player stats, roster, injuries ›
San Francisco 49ers team pageFull player stats, roster, injuries ›This information is for entertainment purposes only and is not any form of financial or gambling advice. Sports involve high variance therefore always be responsible and manage your risk accordingly.
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