Buffalo Bills vs Detroit Lions Prediction, Picks and Head-to-Head

Buffalo BillsVS

Detroit Lions

Head to Head

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Our Picks in This Matchup

Every breakdown we have published between these two teams, graded against the final score.

Side Picks

1-0 · 100%

Total Picks

1-0 · 100%

Thu, Sep 17 · BUF 41, DET 31

W Buffalo Bills -5.5W Over 54.5

›

Head to Head

Every meeting this season and last.

Bills wins

Lions wins

Bills won 41-31

Thu, Sep 17 · at Bills

Team Comparison

2026 season.

Bills		Lions
4-1	Record	3-2
2-1	Home	2-0
2-0	Road	1-2
W1	Streak	W1

Season stats, league rank in brackets. Longer bar, stronger league standing.

31.8 (1st)

Points

(3rd) 31.0

(League Avg: 23.1 Pts/Game)

398.8 (7th)

Total Yards

(9th) 388.0

(League Avg: 346.9 Yds/Game)

247.2 (12th)

Pass Yards

(8th) 247.7

(League Avg: 221.5 Pass Yds/G)

139.0 (5th)

Rush Yards

(9th) 120.7

(League Avg: 112.0 Rush Yds/G)

53.3% (2nd)

3rd Down

(13th) 41.2%

(League Avg: 39.3%)

68.8% (9th)

Red Zone TD

(6th) 78.6%

(League Avg: 59.9%)

6.70 (3rd)

Yards/Play

(9th) 5.85

(League Avg: 5.61 Yds/Play)

7 (25th)

Giveaways

(1st) 1

(League Avg: 5 Giveaways)

26.8 (25th)

Points Allowed

(32nd) 31.7

(League Avg: 23.0 Pts/Game)

390.0 (28th)

Yards Allowed

(32nd) 443.7

(League Avg: 346.7 Yds/Game)

256.2 (27th)

Pass Yds Allowed

(32nd) 299.3

(League Avg: 221.4 Pass Yds/G)

116.0 (19th)

Rush Yds Allowed

(23rd) 117.3

(League Avg: 111.8 Rush Yds/G)

40.7% (20th)

3rd Down Def

(31st) 56.1%

(League Avg: 39.3%)

68.8% (24th)

Red Zone Def

(31st) 84.6%

(League Avg: 59.8%)

10 (8th)

Sacks

(2nd) 12

(League Avg: 9 Sacks)

5 (13th)

Takeaways

(11th) 4

(League Avg: 5 Takeaways)

Buffalo Bills team pageFull player stats, roster, injuries ›

Detroit Lions team pageFull player stats, roster, injuries ›

This information is for entertainment purposes only and is not any form of financial or gambling advice. Sports involve high variance therefore always be responsible and manage your risk accordingly.

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