Buffalo Bills vs Los Angeles Chargers Prediction, Picks and Head-to-Head

Buffalo BillsVS

Los Angeles Chargers

Head to Head

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Our Picks in This Matchup

Every breakdown we have published between these two teams, graded against the final score.

Side Picks

1-0 · 100%

Total Picks

0-1 · 0%

Sun, Sep 27 · BUF 24, LAC 16

W Buffalo Bills -4.5L Over 49.5

›

Head to Head

Every meeting this season and last.

Bills wins

Chargers wins

Bills won 24-16

Sun, Sep 27 · at Bills

Team Comparison

2026 season.

Bills		Chargers
4-1	Record	0-5
2-1	Home	0-3
2-0	Road	0-2
W1	Streak	L5

Season stats, league rank in brackets. Longer bar, stronger league standing.

31.8 (1st)

Points

(29th) 16.8

(League Avg: 23.1 Pts/Game)

398.8 (7th)

Total Yards

(19th) 325.5

(League Avg: 346.9 Yds/Game)

247.2 (12th)

Pass Yards

(24th) 185.2

(League Avg: 221.5 Pass Yds/G)

139.0 (5th)

Rush Yards

(10th) 121.5

(League Avg: 112.0 Rush Yds/G)

53.3% (2nd)

3rd Down

(23rd) 34.6%

(League Avg: 39.3%)

68.8% (9th)

Red Zone TD

(14th) 58.3%

(League Avg: 59.9%)

6.70 (3rd)

Yards/Play

(23rd) 5.31

(League Avg: 5.61 Yds/Play)

7 (25th)

Giveaways

(31st) 10

(League Avg: 5 Giveaways)

26.8 (25th)

Points Allowed

(24th) 26.5

(League Avg: 23.0 Pts/Game)

390.0 (28th)

Yards Allowed

(17th) 347.2

(League Avg: 346.7 Yds/Game)

256.2 (27th)

Pass Yds Allowed

(13th) 211.8

(League Avg: 221.4 Pass Yds/G)

116.0 (19th)

Rush Yds Allowed

(22nd) 121.8

(League Avg: 111.8 Rush Yds/G)

40.7% (20th)

3rd Down Def

(10th) 36.5%

(League Avg: 39.3%)

68.8% (24th)

Red Zone Def

(11th) 56.2%

(League Avg: 59.8%)

10 (8th)

Sacks

(8th) 10

(League Avg: 9 Sacks)

5 (13th)

Takeaways

(6th) 7

(League Avg: 5 Takeaways)

Buffalo Bills team pageFull player stats, roster, injuries ›

Los Angeles Chargers team pageFull player stats, roster, injuries ›

This information is for entertainment purposes only and is not any form of financial or gambling advice. Sports involve high variance therefore always be responsible and manage your risk accordingly.

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